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نویسندگان
چکیده
The routine application of human pluripotent stem cells (hPSCs) and their derivatives in regenerative medicine and drug discovery will require the constant supply of high cell numbers generated by robust and well-defined processes. Previous studies showed that mTeSRTM1 is the most supportive medium for a novel hPSC culture strategy, namely hPSC propagation and expansion of 3-dimensional (3D) aggregates in suspension culture. This technology has the potential to overcome numerous limitations of conventional surface-adherent, 2-dimensional (2D) cultivation of hPSCs. Stirred tank bioreactors represent well-monitored and controlled systems to optimize and up-scale cell production in suspension culture. We have recently shown proof of principle for the expansion of undifferentiated hPSCs in stirred bioreactors in mTeSRTM1. However, substantial optimization is still required to achieve higher process efficiency, robustness, and up-scaling. Here we show that perfusion feeding can result in more homogenous culture conditions and substantially increased hPSC yields compared to previously reported batch feeding methods.
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